abstract：PURPOSE:The aim of this study was to determine the effects of single-dose intravitreal bevacizumab on the levels of vascular endothelial growth factor (VEGF) in serum and distant organs. METHODS:Adult New Zealand albino rabbits (n = 40) were divided into experimental and control groups. Experimental rabbits received a...

journal_title：Cutaneous and ocular toxicology

authors： Dınc E,Yıldırım O,Necat Yılmaz S,Canacankatan N,Ayaz L,Ozcan T,Temel GO

更新日期：2014-12-01 00:00:00

abstract：:The most common side effects of interferon-beta therapy following subcutaneous administration include pain, inflammation and induration at the injection site, which occur in approximately 20-60% of patients. Besides, transient injection-site erythema is frequently seen in beta-interferon therapy. Less frequent reactio...

journal_title：Cutaneous and ocular toxicology

authors： Ozuguz P,Kacar SD,Karaca S,Tokyol C

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Paederus dermatitis (PD), which is an irritant contact dermatitis, is common throughout the world and caused by rove beetles. OBJECTIVES:To assess the clinical features of PD and the level of knowledge of patients from the city of Batman and surrounding areas who presented with the condition. METHODS:We de...

journal_title：Cutaneous and ocular toxicology

authors： Turan E

更新日期：2014-09-01 00:00:00

abstract：:Fixed drug eruption (FDE) is a rare form of drug allergies that recur at the same cutaneous or mucosal site in every usage of drug. Single or multiple round, sharply demarcated and dusky red plaques appear soon after drug exposure. Ursodeoxycholic acid (UDCA: 3α,7β-dihydroxy-5β-cholanic acid) is used for the treatment...

journal_title：Cutaneous and ocular toxicology

authors： Ozkol HU,Calka O,Dulger AC,Bulut G

更新日期：2014-09-01 00:00:00

abstract：CONTEXT:Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models. OBJECTIVE:The objective of this project was to develop an exposure system for delivering controlled vapor conce...

journal_title：Cutaneous and ocular toxicology

authors： Snider TH,Perry MR,Richter WR,Plahovinsak JL,Rogers J,Reid FM,Graham JS

更新日期：2014-06-01 00:00:00

abstract：CONTEXT:Nicorandil is an antianginal drug used for 20 years in Japan and introduced in France in 1994. Since 1997, side effects such as mucocutaneous ulcerations have regularly been reported. OBJECTIVE:To describe the first case of a patient with a spontaneous corneal perforation associated with mucocutaneous ulcerati...

journal_title：Cutaneous and ocular toxicology

authors： Campolmi N,Guy C,Cinotti E,Forest F,Gain P,Philippe-Zech C,Gauthier AS,Thuret G

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Welding workers' ophthalmic problems resulting from their professions are frequently observed in ophthalmic emergencies and can cause severe visual impairment. We aimed to investigate the use of topical anesthetic and non-medical alternatives of this population regarding ophthalmic problems in this study. MATE...

journal_title：Cutaneous and ocular toxicology

authors： Aslan L,Sucakli MH,Bozkurt S,Aslankurt M,Aksoy A,Celik M

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To assess the incidence of seizures induced by cycloplegic ophthalmic drops. MATERIALS AND METHODS:A survey among members of the American Association for Pediatric Ophthalmology and Strabismus yielded five patients who received cycloplegic eye drops between 1998 and 2010 and who consequently developed a seiz...

journal_title：Cutaneous and ocular toxicology

authors： Wygnanski-Jaffe T,Nucci P,Goldchmit M,Mezer E

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The aim of this study is to evaluate the effect of early amniotic membrane transplantation (AMT) in patients with topical proparacaine-related toxic keratopathy. MATERIALS AND METHODS:Between 2008 and 2011, eight eyes of seven patients with toxic keratopathy related to 0.5% proparacaine abuse underwent early A...

journal_title：Cutaneous and ocular toxicology

authors： Burcu A,Dogan E,Yalniz-Akkaya Z,Ornek F

更新日期：2013-09-01 00:00:00

abstract：:Erythema multiforme (EM) is an immune-mediated mucocutaneous eruption characterized by symmetrically distributed, polymorphic targetoid lesions, mostly on the distal parts of the extremities. It occurs mostly in the setting of an infection in certain predisposed individuals. A 30-year-old pregnant woman was presented ...

journal_title：Cutaneous and ocular toxicology

authors： Özyurt S,Er O,Afsar FS,Ermete M

更新日期：2013-09-01 00:00:00

abstract：:Basal cell carcinoma (BCC), the most frequent malignant skin tumor observed in Caucasian adults, especially males, occurs mainly in sun-exposed areas of the body. BCC in the periungual tissues, such as proximal nail fold, nail matrix, nail bed and hyponychium, is rarely reported. We report a patient with two synchrono...

journal_title：Cutaneous and ocular toxicology

authors： Dika E,Patrizi A,Fanti PA,Alessandrini A,Sorci R,Piraccini BM,Vaccari S,Misciali C,Maibach HI

更新日期：2013-06-01 00:00:00

abstract：:In the EU, Methylisothiazolinone (MI) was approved as a preservative in cosmetics and household products in 2005. Since then, several cases of MI contact allergy have been reported. We studied the prevalence of MI sensitization in patients allergic to Methylchloroisothiazolinone/Methylisothiazolinone (MCI/MI). From a ...

journal_title：Cutaneous and ocular toxicology

authors： Macias VC,Fernandes S,Amaro C,Santos R,Cardoso J

更新日期：2013-06-01 00:00:00

abstract：CONTEXT:A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series. OBJECTIVE:To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the pa...

journal_title：Cutaneous and ocular toxicology

authors： Onelmis H,Sener S,Sasmaz S,Ozer A

更新日期：2012-12-01 00:00:00

abstract：:Chemical sensitization is a serious condition caused by small reactive molecules and is characterized by a delayed type hypersensitivity known as allergic contact dermatitis (ACD). Contact with these molecules via dermal exposure represent a significant concern for chemical manufacturers. Recent legislation in the EU ...

journal_title：Cutaneous and ocular toxicology

authors： McKim JM Jr,Keller DJ 3rd,Gorski JR

更新日期：2012-12-01 00:00:00

abstract：:Dicyclohexylcarbodiimide (DCC) and Diisopropylcarbodiimide (DIC) are two representative chemicals in the carbodiimide class of chemicals used in industry as stabilizing agents. There is a potential of dermal exposure to these agents in chemical, pharmaceutical and recombinant DNA industries. The National Toxicology Pr...

journal_title：Cutaneous and ocular toxicology

authors： Surh I,Behl M,Elmore SA,Chhabra RS

更新日期：2012-09-01 00:00:00

abstract：:The most common adverse effects of oral isotretinoin (>1/10) are: cheilitis, skin dryness, erythema, itching, scaling, bruising, skin atopy, conjunctivitis, dry eyes and eyelid inflammation. The aim of this work was to define an optimal dose regime of the oral isotretinoin allowing for effective reduction of sebum pro...

journal_title：Cutaneous and ocular toxicology

authors： Bergler-Czop B,Brzezińska-Wcisło L

更新日期：2012-09-01 00:00:00

abstract：:We report a 9-month-old male patient with autoimmune enteropathy treated with intravenous methylprednisolone who developed firm, red, subcutaneous nodules 20 days after abrupt steroid interruption. The diagnosis of poststeroid panniculitis (PSP) was made based on clinical and histological grounds. PSP is an unusual co...

journal_title：Cutaneous and ocular toxicology

authors： Peralta L,Morais P,Trindade E,Barreto F,Canelhas Á,Amil J

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Delayed keratitis is the most dangerous ocular complication of sulfur mustard (SM) exposure. This study aimed to evaluate the role of tear and serum levels of interleukin-8 (IL-8) in SM exposed subjects. DESIGN AND METHODS:In this historical cohort study, the experimental group included 370 participants who ha...

journal_title：Cutaneous and ocular toxicology

authors： Ghasemi H,Ghazanfari T,Yaraee R,Pourfarzam S,Soroush MR,Faghihzadeh S,Babaei M,Naghizadeh MM,Mohammad Hassan Z

更新日期：2012-06-01 00:00:00

abstract：:Plantago lanceolata, also known as snake's tongue, is a perennial herbaceous plant from the family Plantaginaceae. It is a species widely distributed both in Turkey and all over the world. Today, its fresh leaves are still used to soothe and suppress cough, externally for wound healing and draining abscesses. Phytopho...

journal_title：Cutaneous and ocular toxicology

authors： Ozkol HU,Akdeniz N,Ozkol H,Bilgili SG,Calka O

更新日期：2012-03-01 00:00:00

abstract：:Phenytoin is commonly used an antiepileptic medication for seizure prophylaxis in patients with brain metastases. In these oncology patients group, phenytoin-induced severe adverse reactions may occur. Antiepileptic, particularly phenytoin-induced severe skin reactions including Stevens-Johnson syndrome (SJS) and bull...

journal_title：Cutaneous and ocular toxicology

authors： Bilgili SG,Calka O,Karadag AS,Burakgazi AZ

更新日期：2011-12-01 00:00:00

abstract：:A brief comment on efficacy and safety of propranolol in the treatment of parotid hemangioma is presented, with illustration of a typical case. ...

journal_title：Cutaneous and ocular toxicology

authors： Zheng JW

更新日期：2011-12-01 00:00:00

abstract：:A snakebite is a serious and important problem in tropical and subtropical cities. A vast majority of snakebites are nonvenomous. However, venomous snakebites may cause local tissue destruction, neuroparalysis, systemic hemorrhage, generalized myotoxicity, and acute renal failure. A 10-year-old boy was brought to the ...

journal_title：Cutaneous and ocular toxicology

authors： Ozkol HU,Karadag AS,Bilgili SG,Calka O

更新日期：2011-12-01 00:00:00

abstract：:Dermal absorption of some chemicals and drugs can cause systemic toxicity. We evaluated several case reports from the past decade, which discuss the dermal absorption of a specific chemical and potential local and systemic effects. We focused on herbicide and pesticide exposure along with exposure to cutaneous medicat...

journal_title：Cutaneous and ocular toxicology

authors： Alikhan FS,Maibach H

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Hydrofluoric acid (HF) is a small and partially dissociated acid (pK(a) 3.2), able to deeply penetrate into human skin in addition to the corrosiveness of the hydrogen ion (H(+)) and the toxicity of the fluoride ion (F(-)). However, there has been a lack of experimental studies to objectively characterize th...

journal_title：Cutaneous and ocular toxicology

authors： Burgher F,Mathieu L,Lati E,Gasser P,Peno-Mazzarino L,Blomet J,Hall AH,Maibach HI

更新日期：2011-06-01 00:00:00

abstract：:Attempts to improve formulation of topical products are a continuing process and the development of micro- and nanovesicular systems as well as polymeric microparticles has led to marketing of topical drugs and cosmetics using these technologies. Encapsulation of some well-known contact allergens in ethanolic liposome...

journal_title：Cutaneous and ocular toxicology

authors： Madsen JT,Vogel S,Johansen JD,Andersen KE

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:To evaluate the effect of tolterodine on pupil diameter and anterior chamber parameters, including volume, depth, and angle, with the Pentacam. METHODS:The 56 eyes of 28 patients who were diagnosed as having overactive bladder and planned to be treated with tolterodine were followed up prospectively in the ...

journal_title：Cutaneous and ocular toxicology

authors： Goktas A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:There is increasing interest in minimally invasive skin sampling techniques to assay markers of molecular biology and biochemical processes. OBJECTIVE:This overview examines methodology strengths and limitations, and exciting developments pending in the scientific community. MATERIALS AND METHODS:Publicati...

journal_title：Cutaneous and ocular toxicology

authors： Wang CY,Maibach HI

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:This report, the second in a series of five, directly compares the efficacy of Reactive Skin Decontamination Lotion (RSDL), the M291 Skin Decontamination Kit (SDK), 0.5% bleach (sodium or calcium hypochlorite solution), 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACW...

journal_title：Cutaneous and ocular toxicology

authors： Braue EH Jr,Smith KH,Doxzon BF,Lumpkin HL,Clarkson ED

更新日期：2011-03-01 00:00:00

abstract：:We report a case of ophthalmic antibiotic ointment in the anterior chamber following uneventful phacoemulsification surgery. Antibiotic ointment was observed in the superior angle beneath the clear corneal wound one month later. The patient remained asymptomatic for 26 months after surgery until mild iritis developed....

journal_title：Cutaneous and ocular toxicology

authors： Ugurbas SC,Akova YA

更新日期：2010-09-01 00:00:00

abstract：:A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed a spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment with a tapering dose of cortic...

journal_title：Cutaneous and ocular toxicology

authors： Morais P,Baudrier T,Mota A,Cunha AP,Cadinha S,Barros AM,Azevedo F

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To evaluate the effects of the topical application of nondiluted autologous serum on epithelial healing as an adjuvant therapy in rabbit corneal alkali wounds. METHODS:Central corneal alkali wounds were produced on the right eye of 16 rabbits, by a 60-second application of a 6-mm round filter paper soaked in 1...

journal_title：Cutaneous and ocular toxicology

authors： Salman IA,Gündoğdu C

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To describe 8 cases of toxic keratopathy due to abuse of topical anesthetic drugs. METHODS:Clinical findings from patients with toxic keratopathy were investigated retrospectively. RESULTS:Two patients had toxic keratopathy bilaterally. Five of 8 patients had an ocular history of a corneal foreign body, 1 h...

journal_title：Cutaneous and ocular toxicology

authors： Yeniad B,Canturk S,Esin Ozdemir F,Alparslan N,Akarcay K

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT). METHODS:We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were d...

journal_title：Cutaneous and ocular toxicology

authors： Raman R,Pal SS,Krishnan T,Laxmi G,Radke N,Sharma T

更新日期：2010-03-01 00:00:00

abstract：:In this report we present a case of erlotinib-induced trichomegaly in a male patient who received erlotinib for his pancreatic cancer. Trichomegaly as a side effect of epidermal growth factor receptor (EGFR) inhibitor therapy is uncommon in male patients. Also, it has not been reported previously in a patient with pan...

journal_title：Cutaneous and ocular toxicology

authors： Saif MW,Gnanaraj J

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The exact immunopathogenesis of contact hypersensitivity (CH) to mercury remains unclear. OBJECTIVE:The aim of the present study was to assess the role of CD4+ T cells in mercury-induced CH in mice. METHODS:Splenic CD4+ T cells obtained from nonsensitized and mercury-sensitized Balb/c mice were adoptively ...

journal_title：Cutaneous and ocular toxicology

authors： Sumiwi YA,Soesatyo MH,Sosroseno W

更新日期：2010-03-01 00:00:00

abstract：:The Organisation for Economic Co-operation and Development (OECD) Test Guideline 429 for the local lymph node assay (LLNA) indicates a minimum of 4 mice per dose group, or of 5 mice if statistics are required. Recent discussions at the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVA...

journal_title：Cutaneous and ocular toxicology

authors： Basketter DA,Dearman RJ,Kimber I,Gerberick GF,Ryan CA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Sulfur mustard (SM) has been used as a dangerous chemical warfare agent since the early 20th century. Although many descriptive studies about SM-induced ocular injuries are present in the medical literature, few of them have been conducted over a large group with serious ocular involvement. MATERIALS AND ...

journal_title：Cutaneous and ocular toxicology

authors： Ghasemi H,Ghazanfari T,Ghassemi-Broumand M,Javadi MA,Babaei M,Soroush MR,Yaraee R,Faghihzadeh S,Poorfarzam S,Owlia P,Naghizadeh MM,Etezad-Razavi M,Jadidi K,Naderi M,Hassan ZM

更新日期：2009-01-01 00:00:00

abstract：:The purpose of the present study was to measure and compare permeability coefficients (k(p)) and lag times (tau) in human skin and hairless guinea pig (HGP) skin. Paired experiments employed heat-separated epidermal membranes from human and HGP sources mounted on static in vitro diffusion cells. Infinite-dose, saturat...

journal_title：Cutaneous and ocular toxicology

authors： Frasch HF,Barbero AM

更新日期：2009-01-01 00:00:00

abstract：:We report a case of iris atrophy and corneal endothelial decompensation following the inadvertent use of water-based ink for capsular staining during cataract surgery. The anterior chamber was thoroughly irrigated with balanced salt solution after the identification of the wrong dye. Phacoemulsification with minimal u...

journal_title：Cutaneous and ocular toxicology

authors： Kugu S,Erdogan G,Kandemir B,Dogan OK

更新日期：2009-01-01 00:00:00

abstract：:This study assesses the possibility of using an in vitro model as an introduction to clinical human models for evaluating the buffering capacity of skin when an irritant is topically applied. Sodium hydroxide (NaOH) was utilized as a model base with a view to elucidate information on preventing and/or treating base-in...

journal_title：Cutaneous and ocular toxicology

authors： Ayer J,Maibach HI

更新日期：2008-01-01 00:00:00